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Clinical studies involving tobacco users with controlled conventional cigarette compared to e-cigarette with nicotine use showed acute increases in CD40 and P-selectin markers in conventional cigarette and e-cigarette users (165, 178, 180)

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The two studies employed a cohort design, used similar definitions of menthol smoking status and post-ban quitting, and were conducted within 1-2 months of each other at pre-ban (2016) and post-ban (2018), and thus it was reasonable to pool them together to produce more precise estimates of the impact of the menthol ban

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