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At the same time, the clinical populations included in the studies typically consisted of a younger cohort, and hence, it may not be easy to generalize the findings to an older clinical cohort

Thus, upregulation of GPx1 was associated with poor prognosis in some but not all types of renal cell carcinoma: upregulation in kidney chromophobe cell carcinoma and renal clear cell carcinoma was an indicator of a poor prognosis, whereas in renal papillary cell carcinoma, upregulation of GPx1 was associated with better outcomes [135]