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Lastly, a meta-analysis demonstrated that treatment of a degenerated IVD with cells and biomaterials showed better results on disc height restoration and MRI T2 signal intensity than treatment with cells or biomaterial alone

Eric Topol of Scripps Research Translational Institute was more direct: "These peptides have no data to support their safety and efficacy." The clinical proponents argue that the FDA's safety concerns immunogenicity risk, impurity risk, organ toxicity are theoretically valid but speculative in practice