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Risk factors include conditions associated with hypoventilation, such as postoperative status, obstructive sleep apnea, obesity, severe pulmonary disease, neuromuscular disease, and concomitant use of other medications that cause respiratory depression.[see WARNINGS] As with adults, when prescribing codeine for adolescents, healthcare providers should choose the lowest effective dose for the shortest period of time and inform patients and caregivers about these risks and the signs of morphine overdose [see OVERDOSAGE]

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When Phase II detoxification pathways lack the necessary substrates, the highly reactive intermediates created in Phase I can build up in the bloodstream

It acts as a structural and regulatory catalyst for thebiological activity of many enzymes, prote