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Medical supervision is critical when using GLP-1 medications because these drugs can have a major impact on blood sugar levels, appetite, and multiple organ systems

Women using oral contraceptives should consider using a non-oral method or adding a barrier method for 4 weeks after initiating tirzepatide and for 4 weeks after each dose escalation

Further metabolism of pyruvate to Acetyl CoA leads to an increased synthesis of cholesterol (via squalene epoxidase and lanosterol synthase) and fatty acids for phospholipids and energy storage (via malic enzyme, fatty acid synthase, Scd1 and 2)

Binds a pigment receptor Attaches to a melanocyte receptor without needing sun exposure