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Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs

More visible improvements in body composition and energy are typically seen between weeks 4 and 8

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Upon ligand activation, these nuclear ERs dimerize and translocate to the nucleus where they act as transcription factors by binding to estrogen response elements directly or interact with coactivators such as activator protein 1 or specificity protein 1, to regulate gene expression (19)