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When companies market these products using imagery that misleads a child into thinking theyre things theyve consumed before, like a juice box or candy, that can create an imminent risk of harm to a child who may confuse the product for something safe and familiar," said FDA Commissioner Scott Gottlieb.[96] Nicotine toxicity is of concern when e-cigarette solutions are swallowed intentionally by adults as a suicidal overdose.[97] Seizures or convulsions are known potential side effects of nicotine toxicity and have been reported in the scientific literature in relation to intentional or accidental swallowing of e-liquid.[72] Six people attempted suicide by injecting e-liquid.[52] One adolescent attempted suicide by swallowing the e-liquid.[17] Three deaths were reported to have resulted from swallowing or injecting e-liquid containing nicotine.[52] An excessive amount of nicotine for an adult that is capable of being fatal is 0.51 mg/kg of body weight.[15] An oral lethal dose for adults is about 3060 mg.[38] However the widely used human LD 50 estimate of around 0.8 mg/kg was questioned in a 2013 review, in light of several documented cases of humans surviving much higher doses

The report also shows the number of cigarette smokers dropped from 45.1 million in 2005 to 42.1 million in 2013, despite the increasing population in the U.S

[59] A 2018 PHE report stated that the toxicants found in e-cigarette vapor are less than 5% and the majority are less than 1% in comparison with traditional cigarettes