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The clinical significance of this can't be overstated: a drug that patients will actually take consistently outperforms a theoretically superior drug that patients avoid or use inconsistently
The symptoms of mushroom poisoning can vary widely, from just feeling generally unwell, to severe problems including liver or kidney failure, or problems with the nervous system
However, the physiological half-life of GLP-1 in circulation is very short (less than 2 min), which can be attributed to both rapid proteolytic cleavage of the amide bond of alanine at position 8 (Ala8) in the N-terminus by ubiquitous dipeptidyl peptidase IV (DPP-IV), which results in the removal of the two N-terminal amino acids leading to the formation of a truncated inactive form 10,11 and clearance by the kidney as well
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