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B-12 deficiency has also been linked to migraine headaches and menstrual irregularities. Recent research has shown that higher levels of Vitamin B-12 protect against brain changes that happen with aging.People with higher B-12 levels, even those without actual deficiency showed less age-related decline like dementia and Alzheimers disease

The doses used in animal research often far exceed those used therapeutically in humans when adjusted for body surface area