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Segn la informacin de prescripcin de la FDA, el dolor de cabeza (cefalea) se reporta en aproximadamente 5-14% de los pacientes que utilizan semaglutide, dependiendo de la dosis y la indicacin (diabetes tipo 2 o manejo de peso)

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Clinical trials that led to regulatory approval did not identify back pain as occurring at significantly higher rates in treatment groups compared to placebo