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These effects were dose-dependent and generally subsided as the body adapted to weekly dosing schedules

HCG and Trophoblast Invasion Research Research has confirmed that first-trimester human trophoblastic cells specifically extravillous cytotrophoblasts (CTBs) both express hCG/LH receptors and present an invasive phenotype, establishing an autocrine/paracrine role for hCG in regulating the trophoblast invasion that is essential for blastocyst implantation and subsequent placentation

In general, rapid or unexplained weight shifts can signal that something is off and warrant evaluation from a clinician

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