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Results: Evidence indicates local estrogen dominance with progesterone resistance, pervasive immune dysregulation, and oxidative stress with iron-driven ferroptosis that particularly injures granulosa cells, alongside disease-relevant genetic/epigenetic regulators and reproductive-tract/gut microbiome dysbiosis

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Individuals with the following conditions face severe and life-threatening risks and should avoid coffee enemas : Digestive conditions, including Crohns disease, Ulcerative Colitis and Diverticulitis A history of bowel surgery Congestive heart failure Intestinal tumors Gastrointestinal cancer Blood vessel disease Kidney, heart, and liver disease Severe hemorrhoids Abdominal hernias Anemia Allergy to coffee Women who are pregnant or nursing should not undertake a coffee enema