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In fact, the addition of NBDHEX, a strong and specific inhibitor of e-GST and other GST isoenzymes belonging to the alpha, pi and mu classes, 13 did not suppress this additional GST activity (Figure 2b), and curiously the activity was also found in the absence of GSH (Figure 2a)

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Additionally, ligands that are substrates of other BBB transport molecules such as P-glycoprotein, an efflux transport protein whose changes in expression are well-characterized with BBB breakdown in AD and neuroinflammation, similarly may demonstrate regional BBB degeneration in patients with AD (van Assema et al., 2012