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Pour expliquer cette observation, l'hypothse la plus plausible est qu'il existe, en solution aqueuse, un quilibre entre forme ouverte et forme ferme de l'enzyme et que le passage vers la forme ouverte correspond au dplacement de cette hlice amphiphile recouvrant le site actif

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We used 48 h as cut-off value for evaluating the laboratory data, because it is not known how fast the 5-oxoproline levels and the other measured laboratory values change to normal levels after discontinuation of the drugs

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