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In a recent, trimodal approach comprising 18 F-FDG-PET, functional MRI and 18 F-DOPA-PET, evidence was found for network-dependent neurodegeneration in PD by recapitulating the impact of nigrostriatal pathway impairment on putaminal dopamine depletion to striatocortical motor circuit dysfunction, thus providing a biomarker for the quantification of disease progression (Ruppert et al

This makes it potentially safer than phytoestrogens for women in whom estrogen stimulation is a concern, though the evidence base is smaller and the standardization of commercial products is inconsistent

The situation is causing the FDA regulatory headaches and, more seriously, posing potential risks to the public

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