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However, there is a need to standardize parameter measurements (such as TEWL, collagen density, viscoelasticity, etc.) in randomized, placebo-controlled trials in designs that include estrogen-deficient skin in menopausal women with correlations to biomarkers examined in these clinical studies that assist patients and physicians as to how to evaluate, select, and provide the most effective treatments in the future

and, most importantly, we see the same senitization to 5FU with other CI inhibitors, such as IACS-010759, phenformin and carboxyamidotriazole, as we do with metformin

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