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In contrast, our experimental model investigates the direct effect of supra-physiological, unmetabolized CGA on otherwise normal hepatocytesa scenario relevant to overdose or the use of highly concentrated preparations

JMJD3 and NF-B-dependent activation of Notch1 gene is required for keratinocyte migration during skin wound healing

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Based on these findings, we propose that Erastin-induced cell death in EMS tissue is not solely limited to ferroptosis but is also accompanied by necroptosis, further elucidating the complex interplay between these cell death pathways in EMS pathophysiology