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Expression of E-cadherin cell adhesion molecules suppresses melanocyte proliferation, but on the other hand, expression of N-cadherin triggered by trauma or metabolic changes in the microenvironment promotes proliferation and migration of melanocytes, which can then aggregate in nests [4, 6]

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Protein glutathiolation by nitric oxide: an intracellular mechanism regulating redox protein modification

Therefore, it can be applied directly as a topical (graft washing), oral supplement, subcutaneous/intravenous injection, or a combination of multiple routes (similar to the approach applied in our study)