It correlates more strongly with the severity and spread of symptomatology than A plaque deposition, has a stronger association with future cognitive stage than A plaque deposition or MRI markers, and can predict the response to anti-A monoclonal antibodies
Pazienti con diabete di tipo 2 (ATTAIN-2) Sempre a 72 settimane e alla dose massima da 17,2 mg, la perdita di peso media stata del 9,6% , contro il 2,5% del placebo, con una riduzione dellemoglobina glicata di circa 1,8 punti percentuali da un basale dell8,1% (Horn et al., 2025)
Butyrate is known to stimulate GLP-1 secretion from intestinal L-cells through activation of specific receptors
Notably, clinical observations indicate that endocrine therapy resistance is closely associated with oestrogen-dependent redox signal dysregulation mediated by ROS, suggesting that targeting ROS homeostasis may represent a novel breakthrough for reversing drug resistance [127]