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189 Moreover, prostate cancer (PCa) cell-derived lactate induces H3K18la in TAMs, inhibiting the activation and phagocytosis of PC cells, which ultimately promotes the occurrence of the PTEN/p53-deficient aggressive-variant PC

Case 1: Heart failure with reduced ejection fraction (HFrEF) Best choice: SGLT2 inhibitor (e.g., Empagliflozin or Dapagliflozin) Rationale: Proven benefit in reducing HF hospitalization and cardiovascular death

The Safety Vacuum: Unregulated "microdosing" and online vendors are bypassing clinical evaluation, leaving patients at risk for malnutrition and electrolyte imbalances

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