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Since mitochondrial dysfunction has been implicated in vestibular disorders like Mnires disease and age-related vestibular decline [43], it is plausible that GLP-1RA effects on mitochondrial pathways could influence vestibular function in susceptible individuals, particularly those with pre-existing metabolic conditions

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Clinical use of DPP-4 inhibitors

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Novo Nordisk stated that neither clinical trials nor post-marketing data suggest a reasonable possibility that semaglutide causes NAION

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There is also an increased risk of gallbladder disease with GLP-1 receptor agonists

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