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E., Davis, C., Jenkins, B

In these studies, those with electron withdrawing groups in the para position of the phenyl fraction were highlighted as having the greatest activity, in particular compound 69 , containing bromine in this position, showed the best inhibitory activity against XO (IC 50 = 1.79 M), almost 10 times more effective than allopurinol (IC 50 = 10.73 M) (Figure 21)

The dual-action approach of reducing intake while increasing expenditure suggests optimal strategies may differ from traditional weight loss approaches

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