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Reagents Heroin (purity 80.5%) was acquired from the Guizhou Public Security Bureau, dissolved in sterile saline to prepare a stock solution of 10 mg/ml, and stored at 4C

In vitro hepatic models suggested that flavonoids and sulfur-containing compounds in garlic supplements might interfere with the activity of efflux drug transporters of the ATP-binding cassette (ABC) family, including P-glycoprotein, multidrug resistance protein (MRP), and breast cancer-resistance protein (BCRP), which function as ATP-dependent efflux pumps that actively regulate the excretion of a number of drugs limiting their systemic bioavailability

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FDA , case 4:25-cv-00174, whichever is later