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The next decade will bring far more precise moleculesdrugs that target multiple incretin pathways at once and create bigger, faster changes in insulin sensitivity, liver (and visceral) fat, vascular inflammation, and mitochondrial function

Smaller trials in those at high risk of atherosclerosis have reported no benefit of vitamin K 2 supplementation on progression of arterial calcification

Berberine may interact with several medicines through effects on liver enzymes (CYP3A4) and transport proteins (P-glycoprotein), potentially affecting levels of medicines such as ciclosporin, tacrolimus, digoxin and some anticoagulants