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By the 1960s, smoking had exploded, helped by the distribution of cigarettes to soldiers in World War II

Under these circumstances, we would expect that the association between disease and smoking to increase in societies that begin to exert pressures (social, governmental, economic, etc.) against smoking

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The comparisons between the sensitivity thresholds of the various groups were analyzed using the Kruskal-Wallis test (KW) and a linear mixed model covering each locus for a global comparison of repeated measures (The assumption of normality of residuals was not met, nevertheless a mixed model is still robust in terms of parameter estimation) and the MannWhitney U-test (MW) for individual loci comparisons