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221 Dual receptor agonists targeting GLP-1 and GIP, such as tirzepatide, have also exhibited promising efficacy in diabetes management, notably in terms of weight reduction and glycemic control

Furthermore, GLP-1 has beneficial cardiovascular effects in humans by lowering blood pressure and improving myocardial function [20, 21], although in rats this peptide significantly increases arterial blood pressure and heart rate [22, 23]

10.1016/0005-2760(82)90150-3 219 Villalpando-RodriguezG

But heres the kickera massive study tracking over 120,000 people found that most quit taking these medications within two years