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The use of GLP-1 agonists has been associated with a reduced incidence of glaucoma in diabetic patients ( Table 2

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How It Works Orforglipron activates GLP-1 receptors in a glucose-dependent manner, leading to several key effects: Increased insulin secretion Reduced appetite Slower gastric emptying Improved satiety signaling in the brain These mechanisms help reduce caloric intake and stabilize blood sugar levels, which are essential for both fat loss and long-term metabolic health