Tectoridin (25, 50 and 100 mg/kg), an isoflavone glycoside from the flower of pueraria, could significantly reduce the levels of serum alanine transaminase (ALT), aspartate aminotransferase (AST), and triglyceride (TG) by dose-manner, meanwhile reverse alcoholic steatosis in mice oral administrated with ethanol (5 g/kg), through reversing the decrease in the levels of medium-chain acyl-CoA dehydrogenase, acyl-CoA oxidase and cytochrome P450 4A in peroxisome proliferators-activated receptor (PPAR-) and its related target genes [280]
As this was an observational study that used electronic health records orders to define exposure, these findings reflect associations and may be influenced by residual confounding and the characteristics of a predominantly high-BMI population
A minority of patients experience a prolonged course lasting several months, particularly after long-term use at 20 mg
This effect does not seem to be a result of a whole-body metabolic shift, as these changes were not seen in adipose or skeletal muscle tissue
