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Similarly, increases in intima-media thickness of the common carotid arteries, presence of coronary heart disease, and the presence of peripheral artery disease correlated with the Pro/Leu genotype compared to those homozygous for the Pro allele in a study of type 2 diabetic patients in Japan [91], consistent with a role for this polymorphism in cardiovascular risk

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Selenium supplementation could visibly reduce the serum levels of FT3, FT4, and TPOAb in patients with AITD, but no observable effects were detected on the levels of TSH and TGAb [65]