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Johnson JA, Majumdar SR, Simpson SH, Toth EL: Decreased mortality associated with the use of metformin compared with sulfonylurea monotherapy in type 2 diabetes

Hypoxia-inducible factor 1-alpha (HIF-1) induced oxidative stress that regulates vimentin gene transcription aided cancer cell invasion and migration by facilitating invadopodia formation [47]

Each receptor contributes differently to the GI disruption

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