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If the resynthesis of GSH is impaired or if the oxidation rate is greater than resynthesis under the effect of HRCC cigarettes, the level of GSSG remains high, reducing the GSH/GSSG ratio (Lambertucci et al., 2007)

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We used the BPRF for each riskoutcome pair to calculate riskoutcome scores (ROSs) and categorize the strength of evidence for the association between smoking and each health outcome using a star rating from 1 to 5