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The narrowing puts pressure on your nerve roots and spinal cord, which leads to pain, numbness, weakness, and tingling in your neck or lower back

Other consequences of kidney toxicity related to NSAID use include high blood pressure, salt and water retention, and electrolyte imbalances (Ejaz 2004)

Considering the reduced biosynthetic capacity of erythrocytes, they accumulate oxidative changes along their life span and, therefore, the OS-induced changes in RBCs could be used as useful biomarkers in several pathological and physiological conditions

We also know it extends beyond excruciating pain, to light sensitivity and nausea