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By Product 8.3.4.2.3

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10.1111/fcp.12665 13 GhoshS.KhazaeiM.Moien-AfshariF.AngL

(2.1) The recommended starting dose in patients not currently treated with metformin is 100 mg sitagliptin and 1000 mg metformin HCl once daily, with gradual dose escalation recommended to reduce the gastrointestinal effects due to metformin