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Substrate receptor proteins, such as von Hippel-Lindau tumor suppressor (VHL), suppressor of cytokine signaling (SOCS) (Figure 1) ( FIGURE 1 3 A unifying framework: the determinants of CUL5s context-dependent functions As the scaffold protein of the CRL5 complex ( 3.1 SOCS and CUL5 The SOCS protein family comprises eight members, which bind to Elongin B/C and recruit CUL5 to form CRL5 complexes

But, theres one side effect thats become harder to ignore: Ozempic Face. As patients lose weight rapidly, especially in the face, many notice deflated cheeks, sagging jawlines, and fine lines that seem to appear overnight