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Hagihara M, Kuroki Y, Ariyoshi T, Higashi S, Fukuda K, Yamashita R, Matsumoto A, Mori T, Mimura K, Yamaguchi N, Okada S, Nonogaki T, Ogawa T, Iwasaki K, Tomono S, Asai N, Koizumi Y, Oka K, Yamagishi Y, Takahashi M, Mikamo H (2020) Clostridium butyricum Modulates the Microbiome to Protect Intestinal Barrier Function in Mice with Antibiotic-Induced Dysbiosis

For those with diabetes or obesity, this is a significant factor