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4.1 Clinical relevance of the CLP model The CLP model was selected for its unique ability to recapitulate core clinical features of SAE: polymicrobial sepsis, hippocampal neurodegeneration, and chronic cognitive impairment (Yin et al., 2023)

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Interestingly, estrogen receptors ER and ER are located in the axons and synaptic terminals of pre-synaptic cells and also in the dendritic spines (structures crucial for synaptic transmission) of post-synaptic cells (McEwen and Milner, 2007), indicating a role in local regulation of synapsis instead of exerting an effect at nuclear transcription (Zarate et al., 2017)

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