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Pregnant women with Hashimoto's typically require increased levothyroxine doses and should receive specialist endocrinology input

158 G-CSF, in contrast to GM-CSF, upregulates NAMPT, triggering NAD/SIRT1 granulopoiesis via C/EBP/ upregulation

It has been postulated that these clinical features may arise from the accumulation of potentially toxic substrates, particularly in the so-called intoxicating IEMs, or alternatively due to product deficiency [5]

Vasculogenesis is also described in adults during capillary formation post ischemia [41] or in tumors as alternative mechanism for neo-vascularization to meet the increasing need for oxygen and nutrient supply [42]