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However, a trend was observed between habitual intake of dietary L-carnitine and the increase in TMAO from baseline to 24 h (Figure 4C

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Considering that P1 in rats corresponds to approximately 23 weeks gestation in humans, and P8 around delivery (101), these findings suggest that mid-gestational exposure to VPA produces excitatory-dominant E/I imbalance by blocking the excitatory-to-inhibitory shift of GABAergic signaling or reducing VGAT expression and decreasing GABA synthesis in the postnatal brain