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Acetyl coenzyme A is transported to the cytoplasm through the citric acid-isocitric acid cycle, where it participates in fatty acid synthesis (Mullen et al., 2014

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Furthermore, NRF2 controls genes encoding enzymes governing different metabolic pathways, such as lipogenesis and lipid degradation, lipid transport and uptake, enzymes of the pentose phosphate pathway, and some enzymes of glycogen metabolism, like glycogen branching enzyme (GBE) and phosphorylase b kinase subunit A1 (PHKA1), recently linked to NRF2 signalling in the muscle [165] (Fig