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Epithelial tissue-specific transgenic mice To achieve conditional airway epithelial specific deletion, C57BL/6 mice containing floxed Miro1 alleles (Miro1 flx/flx ) (34) were crossed with double transgenic mice containing a Club Cell secretory protein (CCSP) promoter fused to a reverse tetracycline trans activator (rTetA) and a Tet operon fused to Cre recombinase (TetOP-Cre), termed CCSP-rTetA/TetOP-Cre (44), to generate triple transgenic (CCSP-rTetA/TetOP-Cre/Miro1 flx/flx ) mice, referred to as Epi-Miro1

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