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Ann N Y Acad Sci 1069 : 322345 Shepshelovich D and Shoenfeld Y (2006) Prediction and prevention of autoimmune diseases: additional aspects of the mosaic of autoimmunity

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(JT) Japan Tobacco leverages its domestic expertise in heated tobacco to lead market development across the Asia Pacific, capitalizing on the success of its Ploom TECH and Ploom X systems in Japan, where over 30% of adult smokers have switched from cigarettes, as reported in JTs 2023 sustainability review

Toxicants present in CS and e-vapor increase secretion of ROS that can further induce cell stress responses, such as proinflammatory pathways, unfolded protein response pathways, and alterations in cell differentiation, including goblet cell hyperplasia [71]