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Approved Agents and Their Pharmacokinetic Profiles | Agent | Brand | Half-Life | Route | Primary Indication | |---|---|---|---|---| | Semaglutide | Ozempic / Wegovy / Rybelsus | ~7 days | SC weekly or oral daily | T2DM / obesity | | Liraglutide | Victoza / Saxenda | ~13 hours | SC daily | T2DM / obesity | | Tirzepatide | Mounjaro / Zepbound | ~5 days | SC weekly | T2DM / obesity (GIP+GLP-1) | | Dulaglutide | Trulicity | ~5 days | SC weekly | T2DM | | Exenatide IR | Byetta | ~2.4 hours | SC twice daily | T2DM | | Exenatide ER | Bydureon BCise | ~2 weeks | SC weekly | T2DM | Tirzepatide is technically a dual GIP/GLP-1 receptor agonist, but it is managed clinically within the same adverse-event framework as pure GLP-1 agents [1]