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Future work should prioritize long-term safety and personalized therapeutic strategies to optimize GLP-1RA use in T2D management

Takeaway Jorge Plutzky, M.D., a Mass General Brigham cardiologist who was instrumental in designing and running the trial as a steering committee member, noted that the landmark study means semaglutide could help large numbers of patients with heart disease in the future

Reported preclinical effects Within the constraint that the mechanism is unresolved, the preclinical literature on synthetic DSIP describes a recurring pattern of effects on sleep, stress and opioid-system interactions, summarized below

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