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Cohorts of rats were divided into 8 groups with the following conditions and treated for a course of 28 days: The study concluded that hydroquinone caused structural disruptions to the region of the epidermis that overlays keratin, which is essential for structure and barrier function of the skin

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The remaining share is split among other brands owned by these same companies

The peak urine concentration occurs roughly 3 to 5 hours after taking the dose and remains above the 1,000 ng/mL detection threshold for at least 24 to 48 hours in most adults