Yen, F.S., Wang, S.I., Hsu, C.C., Hwu, C.M
From Opioid Peptides to a Selective Pentapeptide Ipamorelin (developmental code NNC 26-0161) is a synthetic pentapeptide, Aib-His-D-2-Nal-D-Phe-Lys-NH2, that acts as an agonist at the growth hormone secretagogue receptor (GHS-R1a)
GLP-1 Receptor Agonists and the Eye: Evidence, Mechanisms, and Clinical Guidance A new multidisciplinary expert consensus published in Diabetes, Obesity & Metabolism (2025) brings clarity to a question often raised in clinical practice: Do GLP-1 receptor agonists increase the risk of ocular complications such as diabetic retinopathy or optic neuropathy
Multivariate analysis of fasting glucose showed that fasting glucose was lower in the placebo arm at 12 months (2.2 mmol/L 95%CI: 0.4, 4.1, p = 0.027) but not at 6 months (1.4 mmol/L, 95%CI 1.1, 3.9, p = 0.24) (Supplementary Tables 10.1 and 10.2)