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In contrast, curcumin demonstrates preferential inhibition of COX-2 over COX-1

There are two main symptoms of peripheral neuropathy in patients with CIPN: one is a gain of function manifestation (characterized by burning pain, pinprick sensation, and sensitivity to cold and touch), and the other is a loss of function manifestation (characterized by loss of proprioception, diminished vibration and pinprick sensation, accompanied by numbness) [6,7,8]

Remember, every individuals skin is unique, and the time it takes to achieve your desired skin tone can vary

Under normal conditions, the activity of the Nrf2-mediated transcription is low, as most of Nrf2 protein is degraded in the proteasome (Itoh et al., 2003)