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ANSWER: Meta-analyses evaluating the A1C-lowering impact of adding a DPP-4 inhibitor or SGLT2 inhibitor to metformin have shown either no significant differences between the two classes or a small difference (0.11% to 0.17%) in favour of SGLT2 inhibitors

Do Not Shake: Swirl the vial with a gentle, circular wrist motion until the solution clarifies into a fully transparent liquid