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L'encapsulation du Cidofovir peut tre optimise en jouant sur les paramtres suivants :The encapsulation of Cidofovir can be optimized by playing on the following parameters: - Augmentation de la concentration de solution de dpart - Plusieurs cycles d'imprgnation- Increasing the concentration of starting solution - Several impregnation cycles - Diffrents temps d'imprgnation- Different impregnation times - Utilisation de diffrents solides avec une plus grande capacit (MILlOl biphenyl, MIL88D modifie avec diffrents groupes organiques) et de solides hybrides avec des ligands modifies (NH2, Cl, NO2 , CH3, COOH, etc) pour optimiser les interactions mdicament- solide - En fonction des rsultats d'encapsulation, nous utiliserons des nanoparticules de solides modifis en surface avec du PEG pour des tests d'encapsulation.- Use of different solids with greater capacity (MILlOl biphenyl, modified MIL88D with different organic groups) and hybrid solids with modified ligands (NH2, Cl, NO2, CH3, COOH, etc.) to optimize drug-solid interactions - Depending on the encapsulation results, we will use nanoparticles of surface-modified solids with PEG for encapsulation tests