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In the SURPASS-2 trial (published in The New England Journal of Medicine in 2021), tirzepatide at 5, 10, and 15 mg was compared with semaglutide 1 mg in 1,879 adults with type 2 diabetes on metformin over 40 weeks

The SCFAs not metabolized in colonocytes enter the portal circulation of the liver through the basolateral membrane and provide substrates for energy metabolism in hepatocytes

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