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Description

Free Radical Biol Med (2019) 133:4654

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At the mechanistic level, PRR specifically binds to the cysteine-rich region at the C-terminus of DPP4, increasing the level of dipeptidyl peptidase 4 (DPP4) protein, which in turn activates the JNK signaling pathway while inhibiting SIRT3 and fibroblast growth factor receptor 1 (FGFR1) signals, leading to the death of pyroptotic cells (Xie S

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Giurgeas criteria:(1) Enhancement of memory and learning Improved cognition under stress Protection of brain cells (neuroprotective) Facilitation of cell-to-cell communication Backed by human research demonstrating brain bioactivity Absence of usual pharmacological effects of psychotropic drugs By the strictest definition, only a handful of true nootropics exist

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